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1%) were greater in patients treated with rosiglitazone added to metformin compared to monotherapy with rosiglitazone. Significantly more female patients who received rosiglitazone experienced fractures of the upper arm, hand, or foot, than did female patients who received either metformin or glyburide. Overall, anemia and edema were generally mild to moderate in severity and usually did not require discontinuation of treatment with rosiglitazone. 4% on rosiglitazone in combination with maximum doses of metformin. Lower pre-treatment hemoglobin/hematocrit levels in patients enrolled in the metformin and rosiglitazone combination therapy clinical trials may have contributed to the higher reporting rate of anemia in these studies [see Adverse Reactions (6.

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